Stomatitis, vomiting, nausea, anorexia, hiccups, diarrhoea; acute renal toxicity; thrombotic microangiopathy (haemolytic uraemic syndrome), bone marrow failure, neutropenia, Coombs' +ve haemolytic anaemia, myelosuppression, mild bone marrow toxicity; infection, sepsis; anaphylactic & anaphylactic-like reactions; unilateral or bilateral tinnitus &/or hearing loss; convulsion, leukoencephalopathy, reversible posterior leukoencephalopathy syndrome, haemorrhagic & ischaemic stroke, ageusia, cerebral arteritis, myelopathy; retinal toxicity; CV abnormalities; Raynaud's phenomenon, VTE; pulmonary embolism; mild & transient serum AST & ALT elevations; mild alopecia; myalgia, muscle spasm; spermatogenesis & azoospermia impairment; dehydration, serious electrolyte disturbances; pyrexia, asthenia, malaise, local effects.